isoconazole nitrate
isoconazole nitrate
CAS: 24168-96-5
Molecular Formula: C18H15Cl4N3O4
isoconazole nitrate - Names and Identifiers
| Name | isoconazole nitrate |
| Synonyms | Fazol R 15454 24168-96-5 Adestan G 100 Gyno-Travogen isoconazole nitrate Imidazole, 1-[2,4-dichloro-b-[(2,6-dichlorobenzyl)oxy]phenethyl]-, mononitrate (8CI) 1-{2-[(2,6-Dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazol-1-ium nitrate 1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]-1H-imidazolium nitrate 1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]-1h-imidazole mononitrate 1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]-3H-imidazol-1-ium nitrate 1H-Imidazole, 1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]-, mononitrate (9CI) |
| CAS | 24168-96-5 |
| EINECS | 246-051-4 |
| InChI | InChI=1/C18H14Cl4N2O.NO3/c19-12-4-5-13(17(22)8-12)18(9-24-7-6-23-11-24)25-10-14-15(20)2-1-3-16(14)21;2-1(3)4/h1-8,11,18H,9-10H2;/q;-1/p+1 |
isoconazole nitrate - Physico-chemical Properties
| Molecular Formula | C18H15Cl4N3O4 |
| Molar Mass | 479.14 |
| Melting Point | 178-182°C |
| Boling Point | 178-182℃ |
| Solubility | Very slightly soluble in water, soluble in methanol, slightly soluble in ethanol (96 per cent). |
| Appearance | White crystal or crystalline powder |
| Color | White to Off-White |
| Merck | 14,5160 |
| Storage Condition | Sealed in dry,2-8°C |
| Use | Broad-spectrum antifungal agents |
| In vitro study | Isoconazole nitrate also exerts several other effects on the fungal membrane, which are independent of inhibition of the ergosterol synthesis. Isoconazole nitrate (ISN) causes a rapid reduction of cellular adenosine triphosphate (ATP) within 10 min of in vitro exposure. Isoconazole nitrate (1, 10 μg/mL) induces a blockade of cell division in vitro by its action on synthesis and organisation of the cell membrane. Isoconazole nitrate (50, 100 μg/mL), ISN induced necrosis and death of fungal cells. |
isoconazole nitrate - Risk and Safety
| RTECS | NI4772000 |
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